Articles

Lu, H.; Cheng, J. * "Aliphatic Amine-Mediated Controlled Polymerization of α-Amino Acid-N- Carboxyanhydrides", in preparation, 2008

Tong, R.; Cheng, J.* “Site-specific conjugation mediated by metal catalysts”, in preparation,  2008

Lu, H.; Cheng, J. * "Controlled Ring-Opening Polymerization of a-Amino Acid N-Carboxyanhydrides and Facile End Group Functionalization of Polypeptides", accepted, Journal of American Chemical Society, 2008.

Tong, R.; Cheng, J.* “Site-Specific Ring-Opening Polymerization for Controlled Formulation of Polylactide Nanoconjugates”, submitted, Journal of American Chemical Society, 2008

Tong, R.; Cheng, J.* “Paclitaxel-Initiated, Controlled Polymerization of Lactide for the Formulation of  Polymeric Nanoparticulate Delivery Vehicles”, Angewandte Chemie International Edition, 2008, 47, 4830-4834. [PDF] 

Teply, BA; Tong, R.; Jeong, SY;  Luther,G.; Sherifi, I.; Yim, CH; Khademhosseini, A.;  Farokhzad,OC; Langer R.*; Cheng J.* "Charge-Coupled Polymeric Microparticles and Micromagnets Allow External Modulation of the Bioavailability of Orally Delivered Macromolecules", Biomaterials, 2008, 29, 1216-1223. [PDF]

Lu, H.; Cheng, J. * "Hexamethyldisilazane-Mediated Controlled Polymerization of α-Amino Acid-NCarboxyanhydrides", Journal of American Chemical Society, 2007, 129, 14114-14115.[PDF]

Tong, R.; Cheng, J. *“Anticancer Polymeric Nanomedicines”, Polymer Reviews, 2007, 47, 345-381. [PDF]

Karp J.  M., Yeh, J.;, Eng, G. , Fukuda, J.; Blumling, J.; Suh, K. Y.; Cheng, J.; Mahdavi, A.; Jeffrey Borenstein, J.; Langer, R.; Khademhosseini, A.  "Controlling size, shape and homogeneity of embryoid bodies using poly(ethylene glycol) microwells", Lab Chip, 2007, 7, 786 - 794. [PDF]

Cheng, J.; Teply, B.; Sherifi, I.; Sung, J.; Luther. G.; Gu, F.X.; Levy-Nissenbaum, E.; Langer, R. Farokhzad, OC. “Formulation of Functionalized PLGA-PEG Nanoparticles for In Vivo Targeted Drug Delivery”, Biomaterials, 2007, 28, 869–876.[PDF]  Ranked as the No. 1 of the top 25 hottest articles downloaded in Biomaterials. (December, 2006).

Farokhzad, OC; Cheng J. (co-first author), Teply, B.A.; Sherifi I.; Khademhosseini A.; Langer, R. “In vivo prostate tumor reduction after single administration of docetaxel encapsulated nanoparticle-aptamer bioconjugates”, Proceedings of the National Academy of Sciences, 2006, 103, 6315-6320.[PDF]

Cheng, J. Zeidan, R. Mishra, M., Liu, A., Pun, SH., Kulkarni, RP; Jensen, GS,  Bellocq, N., and Davis ME;, Structure-Function Correlation of Chloroquine and Analogues as Transgene Expression Enhancers in Non-Viral Gene Delivery. J. Med. Chem., 2006, 49, 6522-6531.[PDF]

Schluep T., Hwang J., Cheng J., Heidel, J.D.; Derek W., Bartlett, DW, Davis M.E. “Preclinical Efficacy of the Camptothecin-Polymer Conjugate IT-101 in Multiple Cancer Models.” Clinical Cancer Research, 2006, 12, 1606-1614. [PDF]

Cheng, J.; Teply, B. Yim, C.; Jeong, SY, Sherifi, I.; Jon, S.; A. Khademhosseini; Farokhzad, OC; Langer, RS. “Magnetically Responsive Polymeric Microparticles for Oral Delivery of Protein Drugs”, Pharmaceutical Research, 2006, 23, 557-564. [PDF]

Fukuda, J.; Khademhosseini A.; Yeh, J.; Eng, G.; Cheng, J., Farokhzad, OC; Langer, RS. “Micropatterned cell co-cultures using layer-by-layer deposition of extracellular matrix components”, Biomaterials, 2006, 27,1479-86. [PDF]

Schluep, T.; Cheng, J.; Khin KT, Davis, ME “Pharmacokinetics and biodistribution of the camptothecin-polymer conjugate IT-101 in rats and tumor bearing mice”, Cancer Chemotherapy and Pharmacology, 2006, 57, 654-662. [PDF]

Farokhzad, O.; Khademhosseini, A.; Jon, S.; Hermmann, A.; Cheng, J.; Chin, C.; Kiselyuk, A.; Eng, G.; Langer, R. “Microfluidic System for Studying the Interaction of Nanoparticles and Microparticles with Cells” Analytical Chemistry, 2005, 77, 5453-5459. [PDF]

Pun, S. H.; Bellocq, N. C.; Cheng, J.; Grubbs, B. H.; Jensen, G. S.; Davis, M. E.; Tack, F.; Brewster, M.; Janicot, M.; Janssens, B.; Floren, W.; Bakker, A.; “Biodistribution of RNA-cleaving DNA Enzyme (DNAzyme) to Tumor Tissue by Transferrin-Modified, Cyclodextrin-Based Particles”, Cancer Biology and Therapy, 2004, 3, 641-650. [PDF]

Cheng, J.; Khin, K. T.; Davis, M. E. “Antitumor Activity of (β-Cyclodextrin Polymer-Camptothecin Conjugates”, Molecular Pharmaceutics, 2004, 1, 183-193. [PDF]

Cheng, J.; Khin, K. T.; Jensen, G. S.; Liu, A.; Davis, M. E. “Synthesis of Linear, β-Cyclodextrin-Based Polymers and Their Camptothecin Conjugates”, Bioconjugate Chemistry, 2003, 14, 1007-1017. [PDF]

Cheng, J.; Deming, T. J., “Controlled Polymerization of Beta-lactams Using Metal-Amido Complexes: Synthesis of Block Copoly(β-peptides)”, Journal of American Chemical Society, 2001, 123, 9457-9458. [PDF]

Cheng, J.; Deming, T. J. “Synthesis and Conformational Analysis of Optically Active Poly(β-peptides)”, Macromolecules, 2001, 34, 5169-5174. [PDF]

Cheng, J.; Ziller, J. W.; Deming, T. J. “Synthesis of Optically Active β-Amino Acid N-Carboxyanhydrides”. Organic Letters, 2000, 2, 1943-1946. [PDF]

Cheng, J.; Deming, T. J. "Screening of Optically Active Nickel Initiators for Enantioasymmetric Polymerization of α-Benzyl Glutamate-N-Carboxyanhydride". Macromolecules, 1999, 32, 4745-4747. [PDF]

Smith, G. V.; Cheng, J.; Song, R. "New Enantioselective Heterogeneous Catalysts", Catalysts Letters, 1997, 45, 73-78.

Smith, G. V.; Cheng, J.; Song, R. "Enantioselective Hydrogenation of Prochiral C=C Bonds over Nobel Metal Catalysts Supported by β-Cyclodextrin Polymer", Catalysts of Organic Reactions, 1996, 479-484.

Book Chapters

Cheng, J. and Pun, S. H.; “Nanotechnology in Drug Delivery”, In “An Executive’s Guide to Nanotechnology”, Editor: Lynn Foster, Prentice Hall, 2005.

Patents

Cheng, J.; Lu, H.” Controlled Ring-Opening Polymerization of NCA Using Organosilicon Reagents”, provisional application, 2008.

Cheng, J; Tong, R. “Particulate Drug Delivery”, PCT International Application, 2008.

Farokhzad, O.; Cheng, J.; Teply, B.; Langer, R. S. “System for targeted delivery of therapeutics agents”, PCT international application, 2007.

Jon, S.; Farokhzad, O. C.; Langer, R. S.; Cheng, J.  “Coated Controlled Release Polymer Particles as Efficient Oral Delivery Vehicles for Biopharmaceuticals”, PCT. International Application, 2006

Bellocq, N. C.; Cheng, J; Pun, S. H.; Davis, M.E.  “Carbohydrate-Modified Polymers, Compositions and Uses Related Thereto”, PCT. International Application, 2004

Cheng, J; Davis, M. E.; Khin, K. T. “Cyclodextrin-Based Polymers for Therapeutics Delivery”, PCT. International Application, 7,270,808, issued, 2007

Pun, S. H.; Gonzalez, H.; Davis, M. E.; Bellocq, N. C.; Cheng, J. “Complexing agents for compositions containing inclusion complexes”, US 716, 6302, issued, 2007.

Pun, S. H.; Gonzalez, H.; Davis, M. E.; Bellocq, N. C.; Cheng, J. “Compositions containing inclusion complexes”, PCT. International Application, 701,8609, issued, 2006

Deming. T. J.; Cheng, J., "Transition Metal Initiators for Controlled Poly(β-peptide) Synthesis from Beta-Lactam Monomers ", 681,8732, issued, 2004