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Articles
2009
33. Yigit, MV; Mishra, A.; Tong, R.; Cheng, J.; Wong, GCL.; Lu, Y. "Inorganic mercury detection and controlled release of chelating agents from ion-responsive PEG-liposomes", Chem. Biol., 2009, 16, 937-942 [PDF]
32. Chaney, E. J.; Tang, L.; Tong, R.; Rezaeipoor, R.; Cheng, J.; Boppart, S. "Lymphatic Biodistribution of Cy5-LA50/PLA-mPEG5k Nanoparticles for Targeting Metastatic Cells", accepted.
31. Tong, R.; Cheng, J.* “Controlled Synthesis of Camptothecin-Polylactide Conjugates”, submitted
30. Tong, R.; Yala, L.; Fan, TM.; Cheng, J.* “Controlled Formulation of Paclitaxel-Polylactide Conjugate Nanoparticles”, submitted
29. Lu, H.; Wang, J.; Lin, Y.*; Cheng, J.* “One-Pot Synthesis of Brush-Like Polymers via Integrated Ring-Opening Metathesis Polymerization and Polymerization of Amino Acid N-Carboxyanhydrides”, Journal of American Chemical Society, 2009, 131, 13582-13583 [PDF] Highlighted by Chemical and Engineering News.
28. Tong, R.; Christian, D.A.; Tang, L.; Cabral, H.; Baker, J.R. Jr.; Kataoka, K.; Discher, D.; Cheng, J. "Nanopolymeric Therapeutics", MRS Bulletin, 2009, 34, 422-431 [PDF]
27. Cao, Z.; Tong, R.; Xu, W.; Wong, GWL.;* Cheng, J.;*, Lu, Y.* “Reversible cell-specific delivery of chemotherapy drugs using aptamer-functionalized liposomes”, Angewandte Chemie International Edition, 2009, 48, 6494-6498.[PDF]
26. Tong, R.; Cheng, J.* “Ring-Opening Polymerization Mediated-Controlled Formulation of Polylactide Nanoparticles”, Journal of American Chemical Society, 2009, 131, 4744-4754 [PDF]
2008
25. Lee, JS.; Cheng, J.; Kim, KY. "Next Generation Nanosolutions for Cancer Treatment and Diagnosis", Cancer and Chemotherapy Review, 2008, 3, 144-151.[PDF] (invited review).
24. Lu, H.; Cheng, J. * "Controlled Ring-Opening Polymerization of Amino Acid N-Carboxyanhydrides and Facile End Group Functionalization of Polypeptides", Journal of American Chemical Society, 2008, 130, 12562-12563 [PDF]
23. Tong, R.; Cheng, J.* “Paclitaxel-Initiated, Controlled Polymerization of Lactide for the Formulation of Polymeric Nanoparticulate Delivery Vehicles”, Angewandte Chemie International Edition, 2008, 47, 4830-4834. [PDF].
Highlighted by Alliance for Nanotechnology in Cancer, National Cancer Institute, NIH.
22. Teply, BA; Tong, R.; Jeong, SY; Luther,G.; Sherifi, I.; Yim, CH; Khademhosseini, A.; Farokhzad,OC; Langer R.*; Cheng J.* "Charge-Coupled Polymeric Microparticles and Micromagnets Allow External Modulation of the Bioavailability of Orally Delivered Macromolecules", Biomaterials, 2008, 29, 1216-1223. [PDF]
2007
21. Lu, H.; Cheng, J. * "Hexamethyldisilazane-Mediated Controlled Polymerization of α-Amino Acid-NCarboxyanhydrides", Journal of American Chemical Society, 2007, 129, 14114-14115.[PDF]
20. Tong, R.; Cheng, J. *“Anticancer Polymeric Nanomedicines”, Polymer Reviews, 2007, 47, 345-381. [PDF]
19. Karp J. M., Yeh, J.;, Eng, G. , Fukuda, J.; Blumling, J.; Suh, K. Y.; Cheng, J.; Mahdavi, A.; Jeffrey Borenstein, J.; Langer, R.; Khademhosseini, A. "Controlling size, shape and homogeneity of embryoid bodies using poly(ethylene glycol) microwells", Lab Chip, 2007, 7, 786 - 794. [PDF]
18. Cheng, J.; Teply, B.; Sherifi, I.; Sung, J.; Luther. G.; Gu, F.X.; Levy-Nissenbaum, E.; Langer, R. Farokhzad, OC. “Formulation of Functionalized PLGA-PEG Nanoparticles for In Vivo Targeted Drug Delivery”, Biomaterials, 2007, 28, 869–876. [PDF]
Ranked as the No. 1 of the top 25 hottest articles downloaded in Biomaterials.
As of March 2009, this is the most cited research paper (excluding review paper) among 9000+ papers published in the field of drug delivery since 2007 according to ICI Web of Science (59 citation).
2006
17. Farokhzad, OC; Cheng J. (co-first author), Teply, B.A.; Sherifi I.; Khademhosseini A.; Langer, R. “In vivo prostate tumor reduction after single administration of docetaxel encapsulated nanoparticle-aptamer bioconjugates”, Proceedings of the National Academy of Sciences, 2006, 103, 6315-6320. [PDF]
Highlighted by Forbes Magazine as one of the Top Five Nanotechnology Breakthroughs in 2006.
As of March 2009, this is the second most cited research paper (excluding review paper) among 12000+ papers published in the field of drug delivery since 2006 according to ICI Web of Science (129 citation).
16. Cheng, J. Zeidan, R. Mishra, M., Liu, A., Pun, SH., Kulkarni, RP; Jensen, GS, Bellocq, N., and Davis ME;, Structure-Function Correlation of Chloroquine and Analogues as Transgene Expression Enhancers in Non-Viral Gene Delivery. J. Med. Chem., 2006, 49, 6522-6531.[PDF]
15. Schluep T., Hwang J., Cheng J., Heidel, J.D.; Derek W., Bartlett, DW, Davis M.E. “Preclinical Efficacy of the Camptothecin-Polymer Conjugate IT-101 in Multiple Cancer Models.” Clinical Cancer Research, 2006, 12, 1606-1614. [PDF]
14. Cheng, J.; Teply, B. Yim, C.; Jeong, SY, Sherifi, I.; Jon, S.; A. Khademhosseini; Farokhzad, OC; Langer, RS. “Magnetically Responsive Polymeric Microparticles for Oral Delivery of Protein Drugs”, Pharmaceutical Research, 2006, 23, 557-564. [PDF]
13. Fukuda, J.; Khademhosseini A.; Yeh, J.; Eng, G.; Cheng, J., Farokhzad, OC; Langer, RS. “Micropatterned cell co-cultures using layer-by-layer deposition of extracellular matrix components”, Biomaterials, 2006, 27,1479-86. [PDF]
12. Schluep, T.; Cheng, J.; Khin KT, Davis, ME “Pharmacokinetics and biodistribution of the camptothecin-polymer conjugate IT-101 in rats and tumor bearing mice”, Cancer Chemotherapy and Pharmacology, 2006, 57, 654-662. [PDF]
2005
11. Cheng, J. and Pun, S. H.; “Nanotechnology in Drug Delivery”, In “An Executive’s Guide to Nanotechnology”, Editor: Lynn Foster, Prentice Hall, 2005.
10. Farokhzad, O.; Khademhosseini, A.; Jon, S.; Hermmann, A.; Cheng, J.; Chin, C.; Kiselyuk, A.; Eng, G.; Langer, R. “Microfluidic System for Studying the Interaction of Nanoparticles and Microparticles with Cells” Analytical Chemistry, 2005, 77, 5453-5459. [PDF]
1997-2004
9. Pun, S. H.; Bellocq, N. C.; Cheng, J.; Grubbs, B. H.; Jensen, G. S.; Davis, M. E.; Tack, F.; Brewster, M.; Janicot, M.; Janssens, B.; Floren, W.; Bakker, A.; “Biodistribution of RNA-cleaving DNA Enzyme (DNAzyme) to Tumor Tissue by Transferrin-Modified, Cyclodextrin-Based Particles”, Cancer Biology and Therapy, 2004, 3, 641-650. [PDF]
8. Cheng, J.; Khin, K. T.; Davis, M. E. “Antitumor Activity of (β-Cyclodextrin Polymer-Camptothecin Conjugates”, Molecular Pharmaceutics, 2004, 1, 183-193. [PDF]
7. Cheng, J.; Khin, K. T.; Jensen, G. S.; Liu, A.; Davis, M. E. “Synthesis of Linear, β-Cyclodextrin-Based Polymers and Their Camptothecin Conjugates”, Bioconjugate Chemistry, 2003, 14, 1007-1017. [PDF]
6. Cheng, J.; Deming, T. J., “Controlled Polymerization of Beta-lactams Using Metal-Amido Complexes: Synthesis of Block Copoly(β-peptides)”, Journal of American Chemical Society, 2001, 123, 9457-9458. [PDF]
5. Cheng, J.; Deming, T. J. “Synthesis and Conformational Analysis of Optically Active Poly(β-peptides)”, Macromolecules, 2001, 34, 5169-5174. [PDF]
4. Cheng, J.; Ziller, J. W.; Deming, T. J. “Synthesis of Optically Active β-Amino Acid N-Carboxyanhydrides”. Organic Letters, 2000, 2, 1943-1946. [PDF]
3. Cheng, J.; Deming, T. J. "Screening of Optically Active Nickel Initiators for Enantioasymmetric Polymerization of α-Benzyl Glutamate-N-Carboxyanhydride". Macromolecules, 1999, 32, 4745-4747. [PDF]
2. Smith, G. V.; Cheng, J.; Song, R. "New Enantioselective Heterogeneous Catalysts", Catalysts Letters, 1997, 45, 73-78.
1. Smith, G. V.; Cheng, J.; Song, R. "Enantioselective Hydrogenation of Prochiral C=C Bonds over Nobel Metal Catalysts Supported by β-Cyclodextrin Polymer", Catalysts of Organic Reactions, 1996, 479-484.
Patents (7 licensed)
Cheng, J.; Reza A. Tong, R. ”Immunosuppression using nanoparticles”, provisional application, 2008.
Chung, LWK; Yang, X.; Cheng, J.; Tong, R. “Small molecule mediated cancer targeting and therapy” provisional application, 2008
Cheng, J.; Lu, H.” Controlled Ring-Opening Polymerization of NCA Using Organosilicon Reagents”, provisional application, 2008.
Cheng, J; Tong, R. “Particulate Drug Delivery”, PCT International Application, 2008.
Farokhzad, O.; Cheng, J.; Teply, B.; Langer, R. S. “System for targeted delivery of therapeutics agents”, PCT international application, 2007, licensed by Bind Bioscience, Inc.
Jon, S.; Farokhzad, O. C.; Langer, R. S.; Cheng, J. “Coated Controlled Release Polymer Particles as Efficient Oral Delivery Vehicles for Biopharmaceuticals”, PCT. International Application, 2006, licensed by Bind Bioscience, Inc.
Bellocq, N. C.; Cheng, J; Pun, S. H.; Davis, M.E. “Carbohydrate-Modified Polymers, Compositions and Uses Related Thereto”, PCT. International Application, 2004, licensed by Insert Therapeutics, Inc.
Cheng, J; Davis, M. E.; Khin, K. T. “Cyclodextrin-Based Polymers for Therapeutics Delivery”, PCT. International Application, 7,270,808, issued in 2007, licensed by Insert Therapeutics, Inc.
Pun, S. H.; Gonzalez, H.; Davis, M. E.; Bellocq, N. C.; Cheng, J. “Complexing agents for compositions containing inclusion complexes”, US 716, 6302, issued in 2007, licensed by Insert Therapeutics, Inc.
Pun, S. H.; Gonzalez, H.; Davis, M. E.; Bellocq, N. C.; Cheng, J. “Compositions containing inclusion complexes”, PCT. International Application, 701,8609, issued, licensed by Insert Therapeutics, Inc.
Deming. T. J.; Cheng, J., "Transition Metal Initiators for Controlled Poly(β-peptide) Synthesis from Beta-Lactam Monomers ", 681,8732, issued in 2004. Licensed.