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Biomaterials and Nanomedicine
Our research focuses on design, synthesis, characterization and evaluation of polymeric and nanostructured biomaterials. We are particularly interested in developing nanomedicines for their applications in drug delivery to improve or enable human disease treatment. Our research covers a broad scope of multidisciplinary areas including chemistry, materials science, nanotechnology, bioengineering and pharmaceutical science.
1. Polymeric Nanoconjugates for Cancer Drug Delivery
We developed drug-initiated, controlled polymerization for the formation of polymeric nanoconjugates for drug delivery applications.
Recent Publication:
Tong, R.; Cheng, J.* “Ring-Opening Polymerization Mediated-Controlled Formulation of Polylactide Nanoparticles”, Journal of American Chemical Society, 2009, 131, 4744-4754
Tong, R.; Cheng, J.* “Paclitaxel-Initiated, Controlled Polymerization of Lactide for the Formulation of Polymeric Nanoparticulate Delivery Vehicles”, Angewandte Chemie International Edition, 2008, 47, 4830-4834.
Tong, R.; Cheng, J. *“Anticancer Polymeric Nanomedicines”, Polymer Reviews, 2007, 47, 345-381
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2. Synthesis and Application of Polypeptide Biomaterials; Polypeptide Hydrogel for Stem Cell Tissue Engineering Application
We discovered trimethylsilyl-carbamate mediated controlled ring-opening polymerization of amino acid N-carboxyanhydrides for the synthesis of polypeptides. We are currently exploring polypeptide hydrogel as 3D scaffolds for stem cell tissue engineering
Recent Publication:
Lu, H.; Wang, J.; Lin, Y.*; Cheng, J.* “One-Pot Synthesis of Brush-Like Polymers via Integrated Ring-Opening Metathesis Polymerization and Polymerization of Amino Acid N-Carboxyanhydrides”, Journal of American Chemical Society, 2009, accepted pending revision.
Lu, H.; Cheng, J. * "Controlled Ring-Opening Polymerization of Amino Acid N-Carboxyanhydrides and Facile End Group Functionalization of Polypeptides", Journal of American Chemical Society, 2008, 130, 12562-12563
Lu, H.; Cheng, J. * "Hexamethyldisilazane-Mediated Controlled Polymerization of α-Amino Acid-NCarboxyanhydrides", Journal of American Chemical Society, 2007, 129, 14114-14115
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3. Aptamer-Mediated Breast and Prostate Cancer Targeting
Recent Publication:
Cao, Z.; Tong, R.; Xu, W.; Wong, GWL.;* Cheng, J.;*, Lu, Y.* “Reversible cell-specific delivery of chemotherapy drugs using aptamer-functionalized liposomes”, Angewandte Chemie International Edition, in press, 2009
Cheng, J.; Teply, B.; Sherifi, I.; Sung, J.; Luther. G.; Gu, F.X.; Levy-Nissenbaum, E.; Langer, R. Farokhzad, OC. “Formulation of Functionalized PLGA-PEG Nanoparticles for In Vivo Targeted Drug Delivery”, Biomaterials, 2007, 28, 869–876.
Farokhzad, OC; Cheng J., Teply, B.A.; Sherifi I.; Khademhosseini A.; Langer, R. “In vivo prostate tumor reduction after single administration of docetaxel encapsulated nanoparticle-aptamer bioconjugates”, Proceedings of the National Academy of Sciences, 2006, 103, 6315-632
Highlighted by Forbes Magazine as one of the Top Five Nanotechnology Breakthroughs in 2006.